The crash was reported around 11:30 p.m. near eastbound Exit 39 after a car crashed into the truck carrying produce, causing it to roll, Connecticut State Police said.
The truck landed on its side and leaked fuel along the highway. The Department of Energy and Environmental Protection responded to the crash to deal with the clean-up, authorities said.
Several people were injured in the crash, though none of their wounds were considered life-threatening.
Police are investigating the crash.
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